Th17 cell based vaccines in mucosal immunity
نویسندگان
چکیده
منابع مشابه
Mucosal Immunity and Vaccines
These mucosal surfaces, while located inside the body, are actually a physical barrier between the outside and the sterile interior cavity of the body known as the “systemic” environment. Critical nutrients, oxygen and other molecules are constantly taken up across these mucosal barriers; however, another important function of the mucous is to keep invading pathogens out [15]. Daily these mucou...
متن کاملCell-Mediated Immunity and Vaccines
1 Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries and Economics, University of Tromso, 9037 Tromso, Norway 2Nofima, Muninbakken 9-13, 9291 Tromso, Norway 3Division of Solid Tumor, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA 4 Janssen Research & Development, LLC, Immunology Discovery, 3210 Merryfield Row, San Diego, CA 92121, U...
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The mucosal surfaces are constantly exposed to incoming pathogens which can cause infections that result in severe morbidity and/or mortality. Studies have reported that mucosal immunity is important for providing protection against these pathogens and that mucosal vaccination is effective in preventing local infections. For many years, the sublingual mucosa has been targeted to deliver immunot...
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The mucosal immune system consists of molecules, cells, and organized lymphoid structures intended to provide immunity to pathogens that impinge upon mucosal surfaces. Mucosal infection by intracellular pathogens results in the induction of cell- mediated immunity, as manifested by CD4-positive (CD4 + ) T helper-type 1 cells, as well as CD8 + cytotoxic T-lymphocytes. These responses are normall...
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High morbidity and mortality of influenza virus infection makes it an important disease world-wide. Mouse is a very well-studied animal model for this disease with similar manifestation to human disease. It would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. Cell mediated immunity (proliferativ...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2013
ISSN: 0952-7915
DOI: 10.1016/j.coi.2013.03.011